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Published TCIMAIL newest issue No.198
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CAS RN: 114-80-7 | Product Number: N0358
Neostigmine Bromide
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Purity: >99.0%(T)
Synonyms:
- (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide
- (3-Hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€50.00
|
1 | 1 |
|
| 25G |
€159.00
|
1 | 15 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N0358 |
Purity / Analysis Method 
|
>99.0%(T) |
| Molecular Formula / Molecular Weight | C__1__2H__1__9BrN__2O__2 = 303.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 114-80-7 |
| Related CAS RN
|
59-99-4 |
| Reaxys Registry Number | 3640678 |
| PubChem Substance ID | 87573710 |
| SDBS (AIST Spectral DB) | 5015 |
| Merck Index (14) | 6464 |
| MDL Number | MFCD00011795 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 99.0 %(after drying) |
| Solubility in Water | almost transparency |
| Drying loss | max. 1.0 % |
| NMR | confirm to structure |
Properties (reference)
| Solubility (soluble in) | Alcohol, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 204-054-8 |
| RTECS# | BR3150000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2924297099 |
Application
競合的な抗コリンエステラーゼ阻害剤，ネオスチグミンブロミド
Neostigmine bromide, a synthetic physostigmine analog, is a competitive cholinesterase inhibitor. Unlike the plant alkaloid physostigmine [P0406], neostigmine bromide has a quaternary nitrogen, hence it more polar and does not cross the blood-brain barrier. Neostigmine bromide induces an increase in acetylcholine (ACh) in the synaptic cleft through reversible inhibition of its hydrolysis by acetylcholinesterase (AChE), and activates peripheral cholinergic nervous system. Neostigmine bromide used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as tubocurarine [C0433]. (The product is for research purpose only.)
References
- The direct action of prostigmine on skeletal muscle; its relationship to the choline esters
- Acetylcholinesterase inhibitors: a patent review (2008 - present)
- LC/MS/MS analysis of quaternary ammonium drugs and herbicides in whole blood
- Modified carbon paste sensor for the potentiometric determination of neostigmine bromide in pharmaceutical formulations, human plasma and urine
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