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CAS RN: 51803-78-2 | Product Number: N0984

Nimesulide


Purity: >98.0%(T)(HPLC)
Synonyms:
  • N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Documents:
1G
€15.00
2   ≥20 
5G
€45.00
5   ≥20 

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Product Number N0984
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__3H__1__2N__2O__5S = 308.31  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 51803-78-2
Reaxys Registry Number 2421175
PubChem Substance ID 253662461
Merck Index (14) 6548
MDL Number

MFCD00079470

Specifications
Appearance Light orange to Yellow to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 148.0 to 152.0 °C
Properties (reference)
Melting Point 150 °C
Maximum Absorption Wavelength 391(H2O) nm
Solubility (soluble in) Dimethylformamide
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 257-431-4
RTECS# PB0970000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
HS Number 2935909099
Application
比較的選択的なシクロオキシゲナーゼ-2 (COX-2) 阻害剤,ニメスリド

Nimesulide, a sulfonanilide compound, is a relatively selective inhibitor of cyclooxygenase-2 (COX-2) and is used as a non-steroidal anti-inflammatory drug (NSAID). Selective inhibition of COX-2 by NSAIDs may have less gastrointestinal toxicity, while inhibition of COX-1 is linked to gastrointestinal ulcer formation. In addition, nimesulide has some unique therapeutic and pharmacological activities. However, nimesulide induced hepatotoxicity is reported.

References


PubMed Literature


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