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Published TCIMAIL newest issue No.198
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CAS RN: 53123-88-9 | Product Number: R0097
Rapamycin
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€70.00
|
11 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | R0097 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__5__1H__7__9NO__1__3 = 914.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 53123-88-9 |
| Reaxys Registry Number | 5848501 |
| PubChem Substance ID | 160871302 |
| Merck Index (14) | 8114 |
| MDL Number | MFCD00867594 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 1.20 to 1.70 % |
| Specific rotation [a]20/D | -145 to -155 deg(C=0.2, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 177 °C(dec.) |
| Specific Rotation | -150° (C=0.2,MeOH) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide, Chloroform, Acetone, Ether, Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H371 : May cause damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. |
Related Laws:
| RTECS# | VE6250000 |
Transport Information:
| HS Number | 2934999090 |
Application
Bone research
References
- Regulation of bone formation using rapamycin-induced BMP2 expression system: influence of implanted cell number
- Rapamycin Promotes the Osteoblastic Differentiation of Human Embryonic Stem Cells by Blocking the mTOR Pathway and Stimulating the BMP/Smad Pathway
- Use of a Stringent Dimerizer-Regulated Gene Expression System for Controlled BMP2 Delivery
Application
Aggresome research
References
- Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition
- Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice
- Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease
Application
Lentivirus vector transduction enhancer
Rapamycin improves lentiviral vector transduction efficiency of hematopoietic stem cells.1,2) Combination of Rapamycin with prostaglandin E2 further improves the efficiency.
References
- 1) Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells
- 2) Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant ex vivo gene therapy settings
Application
Studies of mTOR (mammalian target of rapamycin) Inhibition
References
- mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
- Defining the role of mTOR in cancer
- Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
- Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
- mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
PubMed Literature
Articles/Brochures
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