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CAS RN: 35941-71-0 | Product Number: T3176

Tiaramide Hydrochloride


Purity: >98.0%(T)
Synonyms:
  • 5-Chloro-3-[[4-(2-hydroxyethyl)piperazin-1-yl]carbonylmethyl]-2-benzothiazolinone Hydrochloride
Documents:
25MG
€134.00
1   6  
100MG
€395.00
2   9  

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Product Number T3176
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__1__5H__1__8ClN__3O__3S·HCl = 392.3  
Physical State (20 deg.C) Solid
CAS RN 35941-71-0
Related CAS RN 32527-55-2
Reaxys Registry Number 6081227
PubChem Substance ID 253660473
Merck Index (14) 9424
MDL Number

MFCD01702832

Specifications
Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 160 °C
Solubility in water Completely soluble
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 252-802-7
RTECS# TL7050000
Transport Information:
HS Number 2934999090
Application
Tiaramide Hydrochloride: A Non-Acidic and Non-Steroidal Anti-Inflammatory Agent with No Inhibiting Action of COX

Tiaramide hydrochloride, a benzothiazolinone derivative, is a non-acidic and non-steroidal antiinflammatory drug (NSAID). It has almost the same antiinflammatory activity and analgesic effect as benzydamine hydrochloride [B3751], but does not inhibit cyclooxygenase (COX). (The product is for research purpose only.)

References

  • Antiinflammatory activity of tiaramide hydrochloride, 4-[(5-chloro-2-oxo-3-benzothiazolinyl)acetyl]-1-piperazineethanol hydrochloride
    • K. Tsurumi, Y. Hiramatsu, M. Nozaki, M. Hayashi, H. Fujimura, Arzneim.-Forsch. 1972, 22, 716.
  • Pharmacological actions of tiaramide hydrochloride, a new antiinflammatory drug
    • K. Tsurumi, Y. Hiramatsu, M. Nozaki, M. Hayashi, H. Fujimura, Arzneim.-Forsch. 1972, 22, 724.
  • Central and peripheral analgesic action of nonacidic nonsteroidal anti-inflammatory drugs in mice and rats
    • H. Nakamura, A. Shimoda, K. Ishii, T. Kadokawa, Arch. Int. Pharmacodyn. Ther. 1986, 282, 16.
  • Preparation and evaluation of beads made of different calcium alginate compositions for oral sustained release of tiaramide
  • High performance liquid chromatographic determination of epirizole and tiaramide in pharmaceutical preparations


PubMed Literature


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