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Published TCIMAIL newest issue No.198
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CAS RN: 162635-04-3 | Product Number: T3574
Temsirolimus
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Purity: >95.0%(HPLC)
Synonyms:
- CCI-779
- Rapamycin 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€339.00
|
1 | Contact Us |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3574 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__5__6H__8__7NO__1__6 = 1,030.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 162635-04-3 |
| Reaxys Registry Number | 9985459 |
| PubChem Substance ID | 354335686 |
| Merck Index (14) | 9142 |
| MDL Number | MFCD00934421 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.00005 mg/l 25 °C |
| Solubility (soluble in) | Alcohol, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| RTECS# | VE6257000 |
Transport Information:
| HS Number | 2934999090 |
Application
Temsirolimus: An Inhibitor of Mammalian Target of Rapamycin (mTOR)
Temsirolimus (also called CCI-779) is an inhibitor of mammalian target of rapamycin (mTOR), a serine/threonine protein kinase. Temsirolimus, the C-42 hydroxyl group ester analog of rapamycin [R0097], possesses better water solubility. Similarly to rapamycin, temsirolimus forms a complex with FK506-binding protein-12 (FKBP-12), and this complex binds and specifically acts as an allosteric inhibitor of mTOR. Inhibition of mTOR activity interferes with tumor angiogenesis，and resulted in a G1 growth arrest in treated tumor cells. (The product is for research purpose only.)
References
- Temsirolimus, an Inhibitor of Mammalian Target of Rapamycin (a review)
- Current development of mTOR inhibitors as anticancer agents (a review)
- In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites
PubMed Literature
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