Maintenance notice in CEST time zone (1:00 - 3:30 AM May 17, 2026): Our website is scheduled for maintenance. The website will be available, but some functions may experience errors. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.201
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 6846-35-1 | Product Number: X0001
Xanthane Hydride
×
Purity: >96.0%(HPLC)
Synonyms:
- ADTT
- 5-Amino-3H-1,2,4-dithiazole-3-thione
- 3-Amino-1,2,4-dithiazole-5-thione
- 5-Imino-5H-[1,2,4]dithiazole-3-thiol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
62,00 €
|
5 | ≥60 |
|
|
| 100G |
169,00 €
|
39 | ≥100 |
|
|
| 500G |
542,00 €
|
≥40 | ≥100 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | X0001 |
Purity / Analysis Method 
|
>96.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2H__2N__2S__3 = 150.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 6846-35-1 |
| Reaxys Registry Number | 112403 |
| PubChem Substance ID | 87577871 |
| SDBS (AIST Spectral DB) | 3701 |
| MDL Number | MFCD00051660 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(with Total Nitrogen) | min. 96.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 229-933-3 |
| RTECS# | JO6500000 |
Transport Information:
| HS Number | 2934999090 |
Application
Sulfur-Transfer Reagents for Synthesis of Oligonucleotide Phosphorothioates
References
- Nucleic acid therapeutics: basic concepts and recent developments
- 3H-1,2-Benzodithiol-3-one 1,1-dioxide
- Phosphorothioate Oligonucleotides with Low Phosphate Diester Content: Greater than 99.9% Sulfurization Efficiency with “Aged” Solutions of Phenylacetyl Disulfide (PADS)
- Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
- Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
Application
Xanthane Hydride: A Sulfur-Transfer Reagent for Synthesis of Oligonucleotide Phosphorothioates
Xanthane hydride (3-amino-1,2,4-dithiazole-5-thione), Beaucage Reagent [B3125] and Bis(phenylacetyl) disulfide [B3623] are used as a sulfur-transfer reagent for synthesis of oligonucleotide phosphorothioates via the phosphoramidite method.1-4) In particular, xanthane hydride has advantages because it does not yield oxidizing substances, carbon disulfide and cyanamide as the additional reaction products.2,3) For DNA/RNA synthesizer, xanthane hydride solution is used, such as 0.02 M solution in acetonitrile/pyridine (9:1),1) or 0.20 M solution in pyridine.4)
References
- 1)Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
- 2)Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
- 3)Evidence for the formation of isothiocyanate during sulfurisation of phosphines and phosphites using xanthane hydride
- 4)Synthesis of 5’-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies
PubMed Literature
Documents
Product Articles
[Product Highlights] Sulfur-Transfer Reagents for Synthesis of Oligonucleotide PhosphorothioatesProduct Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.
Other Documents
Related Products
DMT-dG(Ib) Phosphoramidite
| Product # | D5708 |
| CAS RN | 93183-15-4 |
| Purity / Analysis Method: | >98.0%(HPLC) |
DMT-dC(Bz) Phosphoramidite
| Product # | D5701 |
| CAS RN | 102212-98-6 |
| Purity / Analysis Method: | >98.0%(HPLC) |
DMT-dA(Bz) Phosphoramidite
| Product # | D5707 |
| CAS RN | 98796-53-3 |
| Purity / Analysis Method: | >98.0%(HPLC) |
DMT-dT Phosphoramidite
| Product # | D5702 |
| CAS RN | 98796-51-1 |
| Purity / Analysis Method: | >98.0%(HPLC) |