Versatile Reagent for Sulfoximidation

Dimethylsulfoximine (1) is a building block for the synthesis of sulfoximines and utilized in various types of sulfoximidation reactions. The installing method includes such as S_N2 reaction,¹⁾ nucleophilic attack for carbonyl groups^1,4) and cross-coupling reactions,^2,3) and result the target compounds in high yields in each conditions. Furthermore, this functional group can be installed in the late stage of the synthesis during the C-H activation reaction.⁵⁾ It is further anticipated that 1 can be used in medicinal chemistry and development of agrochemicals because of its abundant variation of reaction styles.