Maintenance Notice (5:15 AM - 4:55 PM May 24, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Please select the quantity
Phosphodiesterase 7 Inhibitor
No.177(April 2018)
BRL 50481 (1) is a selective inhibitor of phosphodiesterase 7 (PDE7).1) 1 inhibits human recombinant PDE7 in a competitive manner (Ki = 180 nM). 1 is much less potent against PDE3 and PDE4 (Table 1). In addition, treatment of human mesenchymal stem cell-derived osteoblasts with 1 increased mineralization.2)
Table 1. Selectivity of BRL 50481 (1) to PDE isoenzymes1)
This product is for research purpose only.
References
- 1)Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes
- 2)Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.