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CAS RN: 115262-01-6 | Product Number: B4325

(Bromodifluoromethyl)trimethylsilane


Purity: >98.0%(GC)
Synonyms:
  • Bromodifluoro(trimethylsilyl)methane
Documents:
1G
€74.00
2   ≥20 
5G
€236.00
1   ≥20 

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Product Number B4325
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__4H__9BrF__2Si = 203.10  
Physical State (20 deg.C) Liquid
CAS RN 115262-01-6
Reaxys Registry Number 3535353
PubChem Substance ID 253659955
MDL Number

MFCD18641931

Specifications
Appearance Colorless to Almost colorless clear liquid
Purity(GC) min. 98.0 %
Properties (reference)
Boiling Point 108 °C
Flash point 17 °C
Specific Gravity (20/20) 1.31
Refractive Index 1.41
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H225 : Highly flammable liquid and vapour.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 : Keep container tightly closed.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P403 + P235 : Store in a well-ventilated place. Keep cool.
Related Laws:
Transport Information:
UN Number UN1993
Class 3
Packing Group II
HS Number 2931900090
Application
An Effective Precursor of a Difluorocarbene to Introduce Difluoromethylene Groups

B4325

Difluoromethylenation of alkynes: under a N2 atmosphere, alkynes (0.5 mmol, 1.0 eq.), (bromodifluoromethyl)trimethylsilane (152 mg, 0.75 mmol, 1.5 eq.), tetrabutylammonium bromide (4.8 mg, 0.015 mmol, 0.03 eq.), and toluene (2.0 mL) are added into an oven-dried pressure tube at room temperature. After being heated at 110 °C for 2 h, the reaction mixture is cooled to rt and poured into a saturated Na2CO3 solution (5 mL), followed by extraction with Et2O (2 × 15 mL). The organic layers are combined and dried over anhydrous K2CO3. After the removal of the solvents in vacuo, the residue is subjected to column chromatography (silica gel; petroleum ether : Et3N = 40 : 1) to afford the desired products. [Note: these products are sensitive to acid, so the column must be eluted previously with petroleum ether : Et3N = 10 : 1)].

References


PubMed Literature


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