CAS RN: 857447-79-1 | Product Number: B5440
Bis(tetrabutylammonium) Dihydrogen Pyrophosphate
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|Purity / Analysis Method||>96.0%(T)|
|Molecular Formula / Molecular Weight||C__3__2H__7__4N__2O__7P__2 = 660.90|
|Physical State (20 deg.C)||Solid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Air Sensitive,Hygroscopic,Heat Sensitive|
|Reaxys Registry Number||9031313|
|PubChem Substance ID||354334284|
|Appearance||White to Almost white powder to crystal|
|Purity(Nonaqueous Titration)||min. 96.0 %|
|Hazard Statements||H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
|Precautionary Statements||P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
5-Chloro-saligenyl-N,N-diisopropylphosphoramidite (Reagent I, C3326) is coupled to the 5'-end of the DMT-off oligonucleotide. Oxidation of the formed 5'-phosphite using the same oxidizing reagent used in standard oligonucleotide synthesis leads to support-bonded 5'-cycloSal-oligonucleotides. Reaction with pyrophosphate (Reagent II, B5440) yields the corresponding 5'-triphosphates. The 5'-triphosphorylated oligonucleotides are obtained after cleavage from the support in high purity and excellent yields. The whole reaction sequence was adapted to be used on a standard oligonucleotide synthesizer.
- Solid-Phase Synthesis of DNA and RNA 5’-O-Triphosphates Using cycloSal Chemistry
[Product Highlights] Phosphorous Compounds for the Synthesis of Triphosphonates of Oligonucleotides
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