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Published TCIMAIL newest issue No.198
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CAS RN: 72956-09-3 | Product Number: C2260
Carvedilol
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€87.00
|
Contact Us | 26 |
|
| 25G |
€313.00
|
Contact Us | 31 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2260 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__6N__2O__4 = 406.48 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 72956-09-3 |
| Reaxys Registry Number | 1514452 |
| PubChem Substance ID | 87560280 |
| SDBS (AIST Spectral DB) | 52170 |
| Merck Index (14) | 1873 |
| MDL Number | MFCD00864692 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 115.0 to 119.0 °C |
Properties (reference)
| Melting Point | 117 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Ether, Ethanol |
GHS
| Pictogram |
|
| Hazard Statements | H411 : Toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P391 : Collect spillage. |
Related Laws:
| RTECS# | UA8670000 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Carvedilol: A Nonselective β-Adrenoceptor Antagonist with α1-Receptor Antagonistic Activity
Carvedilol is a nonselective β1 and β2-adrenoceptor antagonist1) with α1-receptor antagonistic activity.2) The ratio of β1:β2 adrenergic activity is 7:1,1) and the ratio of α:β adrenergic activity is 1:8.3) Carvedilol is a racemic mixture, and the β-adrenoreceptor blocking activity is present in the S-(-)-enantiomer and α1-adrenergic blocking activity is present in both R-(+) and S-(-)-enantiomers at equal potency.4) Carvedilol also has antioxidant and antiproliferative effects.5) Furthermore, carvedilol is able to stimulate β-arrestin-mediated signaling.6) (The product is for research purpose only.)
References
- 1)Pharmacological Profile of Carvedilol as a β-Blocking Agent with Vasodilating and Hypotensive Properties.
- 2)Hemodynamic differences between carvedilol and labetalol in the cutaneous circulation
- 3)Vasodilating mechanism and response to physiological pressor stimuli of acute doses of carvedilol compared with labetalol, propranolol and hydralazine
- 4)Clinical pharmacokinetics and pharmacodynamics of carvedilol (a review)
- 5)Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger (a review)
- 6)A unique mechanism of β-blocker action: carvedilol stimulates β-arrestin signaling
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