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CAS RN: 86393-33-1 | Product Number: C2293

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid


Purity: >98.0%(T)(HPLC)
Synonyms:
  • Fluoroquinolonic Acid
Documents:
5G
€21.00
1   ≥20 
25G
€72.00
1   ≥20 

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Product Number C2293
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__3H__9ClFO__3N = 281.67  
Physical State (20 deg.C) Solid
CAS RN 86393-33-1
Reaxys Registry Number 4515704
PubChem Substance ID 87560826
MDL Number

MFCD00792458

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Melting Point 244 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H412 : Harmful to aquatic life with long lasting effects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# VB1993795
Transport Information:
HS Number 2933491090
Application
Amination with morpholine derivatives under microwave irradiation

Reference


Application
Synthesis and metabolic evaluation of azaspirocyclic fluoroquinolones

Typical procedure: KOtBu (191 mg) is dissolve in DMSO (20 mL), azetidinium oxalate (164 mg) is added and the mixture is stirred at rt for 10 min. Then, 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (200 mg) is added, and the yellow mixture is heated to 130 °C and stirred for 5.5 h. Then it is cooled to rt and poured into H2O (75 mL). The precipitate is filtered and dried overnight upon standing. The crude product is purified by suspending in hot CHCl3, and cooling the mixture to rt, when it is filtered. The residue is dried in vacuo to give the pure desired product (166 mg, 68 %).

References


PubMed Literature


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