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Published TCIMAIL newest issue No.199
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CAS RN: 78574-94-4 | Product Number: C3469
Cycloastragenol
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Purity:
Synonyms:
- (3β,6α,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
- Astramembrangenin
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
€42.00
|
1 | 16 |
|
|
| 100MG |
€131.00
|
2 | 1 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | C3469 |
| Molecular Formula / Molecular Weight | C__3__0H__5__0O__5 = 490.73 |
| Physical State (20 deg.C) | Solid |
Storage Temperature 
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 78574-94-4 |
| Reaxys Registry Number | 4238706 |
| PubChem Substance ID | 354335282 |
| MDL Number | MFCD24849201 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 241.0 to 245.0 °C |
| Specific rotation [a]20/D | +50.0 to +55.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 241 °C |
| Specific Rotation | 49° (C=1.37,MeOH) |
GHS
Related Laws:
| RTECS# | GX8265000 |
Transport Information:
| HS Number | 2932190090 |
Application
Cycloastragenol: A Bioactive Triterpenoid Sapogenin Isolated from Astragalus Roots
Cycloastragenol is a bioactive triterpenoid sapogenin isolated from the Chinese herbal medicine Astragalus roots (e.g., Radix Astragali), and the aglycon derivative of astragaloside IV [CAS: 84687-43-4].1,2) It has been reported that cycloastragenol is an interesting bioactive compound. For example, cycloastragenol has been reported as a stimulater of the phosphorylation of extracellular signal-regulated protein kinase (ERK)3), a potent telomerase activator in neuronal cells4,5), and an effective agent to inhibit of endoplasmic reticulum stress.6) (The product is for research purpose only.)
References
- 1)Triterpenoid saponins from Astragalus wiedemannianus Fischer
- 2)Studies on principal components and antioxidant activity of different Radix Astragali samples using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry
- 3)Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types
- 4)Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management
- 5)In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator
- 6)Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium
PubMed Literature
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