CAS RN: 25952-53-8 | Product Number: D1601
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis]
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|Purity / Analysis Method||>98.0%(T)|
|Molecular Formula / Molecular Weight||C__8H__1__7N__3·HCl = 191.7|
|Physical State (20 deg.C)||Solid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Moisture Sensitive,Heat Sensitive|
|Reaxys Registry Number||5764110|
|PubChem Substance ID||87568083|
|SDBS (AIST Spectral DB)||21309|
|Appearance||White powder to crystal|
|Purity(with Total Nitrogen)||min. 97.0 %|
|Purity(Argentmetric Titration)||min. 98.0 %|
|Melting Point||115 °C|
|Solubility in water||Completely soluble|
|Solubility (soluble in)||Alcohol,Dimethylformamide|
|Hazard Statements||H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
|Precautionary Statements||P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
To a solution of Boc-ΔTyr(Cl2Bzl)-OH (307 mg, 0.7 mmol), glycinamide hydrochloride (77.4 mg, 0.7 mmol) and Et3N (0.1 mL, 0.7 mmol) in DMF (7 mL) is added EDC·HCl (148 mg. 0.77 mmol) and HOBt (129 mg, 0.84 mmol) at -10°C. The reaction mixture is stirred for 2 h at 0°C. and overnight at room temperature. After the solution is evaporated, the residual is dissolved in EtOAc. The solution is washed with 4% NaHCO3, 10% citric acid and water. The solution is dried and evaporated. The purification is carried out by silica gel column chromatography to give Boc-ΔTyr(Cl2Bzl)-Gly-NH2 (317 mg, 85% yield).
(Δ means dehydro-form.)
- Y. Shimohigashi, J. W. Dunning Jr., A. J. Kolar, C. H. Stamer, Int. J. Peptide Protein Res. 1983, 21, 202.
- S. J. O’Malley, K. L. Tan, A. Watzke, R. G. Bergman, J. A. Ellman, J. Am. Chem. Soc. 2005, 127, 13496.
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