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CAS RN: 3945-69-5 | Product Number: D2919

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride


Purity: >95.0%(HPLC)
Synonyms:
  • DMTMM
Documents:
5G
€72.00
14   ≥40 
25G
€231.00
18   ≥40 

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Product Number D2919
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__7ClN__4O__3 = 276.72 
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic,Heat Sensitive
CAS RN 3945-69-5
Reaxys Registry Number 8026872
PubChem Substance ID 87560457
MDL Number

MFCD03613550

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 95.0 area%
Purity(with Total Nitrogen) min. 98.0 %(calcd.on dried substance)   
Drying loss max. 17.0 %
Properties (reference)
Solubility (soluble in) Methanol
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H314 : Causes severe skin burns and eye damage.
Precautionary Statements P260 : Do not breathe dust or mist.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
Related Laws:
Transport Information:
UN Number UN3261
Class 8
Packing Group II
HS Number 2934999090
Application
TCI Practical Example: DMTMM-mediated Condensation

Used Chemicals

Procedure

To a solution of 3-phenylpropionic Acid (1.80 g, 12.0 mmol) and 2-phenylethylamine (1.60 g, 13.2 mmol) in MeOH (120 mL) was added DMTMM (3.65 g, 13.2 mmol) and the mixture was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure. Saturated aqueous sodium bicarbonate solution (100 mL) was added to the residue. After being stirred for 10 minutes, the mixture was extracted with diethyl ether (100 mL). The separated organic layer was washed with deionized water (50 mL), 1 mol/L hydrochloric acid (50 mL), deionized water (50 mL) and brine (100 mL), dried over magnesium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by column chromatography (2:1 ethyl acetate / hexane on SiO2), giving white solid (2.54 g, 84%).

Experimenter’s Comments

The reaction mixture was monitored by TLC (hexane : ethyl acetate = 1 : 1, Rf = 0.30) and GC.

Analytical Data (N-Phenylethyl-3-phenylpropaneamide)

1H NMR (400 MHz, CDCl3); δ 7.05–7.28 (m, 10H), 5.31 (br s, 1H), 3.46 (q, J = 6.8 Hz, 2H), 2.92 (t, J = 7.6 Hz, 2H), 2.71 (t, J = 6.8 Hz, 2H), 2.40 (t, J = 7.6 Hz, 2H).

13C NMR (101 MHz, CDCl3); δ 172.0, 140.8, 138.8, 128.7 (2C), 128.6, 128.5, 128.3, 126.4, 126.2, 40.5, 38.5, 35.6, 31.6.

Lead Reference

Other References


Application
Formation of Amides by Condensation of Carboxylic Acids and Amines in Alcohols or Water

Experimental procedure2): DMTMM (182.6 mg, 0.66 mmol) is added to a mixture of 3-phenylpropionic acid (90.1 mg, 0.6 mmmol) and 2-phenylethylamine (80.0 mg, 0.66 mmol) in CH3OH (6.0 mL) at room temperature. After 3 h with stirring at room temperature, the CH3OH is evaporated. The resulting residue is dissolved in ether, and washed successively with saturated sodium carbonate, water, 1 mol/L HCl, water and brine and dried over MgSO4. The crude product is purified by preparative TLC (hexane :EtOAc = 1:2) to give 148.8 mg of 1 (98%)as a colorless crystals.

References


PubMed Literature


Documents (Note: Some products will not have analytical charts available.)
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