CAS RN: 15663-27-1 | Product Number: D3371
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|Molecular Formula / Molecular Weight||H__6Cl__2N__2Pt = 300.05|
|Physical State (20 deg.C)||Solid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Moisture Sensitive|
|PubChem Substance ID||87558796|
|Merck Index (14)||2317|
|Appearance||Light orange to Yellow to Green powder to crystal|
|Elemental analysis(Nitrogen)||8.90 to 9.80 %|
|Melting Point||270 °C|
|Solubility in water||Practically insoluble|
|Degree of solubility in water||2,530 mg/l 25 °C|
|Solubility (soluble in)||Dimethylformamide|
|Hazard Statements||H300 : Fatal if swallowed.
H319 : Causes serious eye irritation.
H360 : May damage fertility or the unborn child.
H362 : May cause harm to breast-fed children.
H370 : Causes damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
H340 : May cause genetic defects.
H350 : May cause cancer.
|Precautionary Statements||P263 : Avoid contact during pregnancy and while nursing.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
The platinum complexes diffuse to the tumor cell, where they undergo hydrolysis displacement of their one chloride or carboxylate group leading to a platinum cation. The resulting cation coordinates to the guanine N7-position of DNA give a coordination cation. Then, intrastrand cross-linking occurs to anther guanine via further hydrolysis displacement of the remaining chloride or carboxylate. The forming [Pt(NH2R)2]2+ ― DNA complex distort the DNA helix (Fig. 1 and 2)6). Thus, DNA duplication is hindered, which ultimately triggers tumor cell apoptosis.3)
- 1)G. Mathe, Y. Kidani, M. Segiguchi, M. Eriguchi, G. Fredj, G. Peytavin, J. L. Misset, S. Brienza, F. de Vassals, E. Chenu, C. Bourut, Biomed. Pharmacother. 1989, 43, 237.
- 2)L. R. Kelland, S. Y. Sharp, C. F. O’Neill, F. I. Raynaud, P. J. Beale, I. R. Judson, J. Inorg. Biochem. 1999, 77, 111.
- 3)D. Wang, S. J. Lippard, Nat. Rev. Drug Discov. 2005, 4, 307.
- 4)S. Trzaska, Chem. Eng. News 2005, 83, 3.
- 5)L. P. Martin, T. C. Hamilton, R. J. Schilder, Clin. Cancer Res. 2008, 14, 1291.
- 6)A. Gelasco, S. J. Lippard, Biochemistry, 1998, 37, 9230.
- Cis-diamminedichloroplatinum (DDP) induced acute renal failure (ARF): attempts at amelioration
- S. Chopra, J. Kaufman, W. Flamenbaum, Clin. Exp. Dial. Apheresis. 1983, 7, 25.
- Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat: enzyme histochemical studies
- Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations
- T. W. Jones, S. Chopra, J. S. Kaufman, W. Flamenbaum, B. F. Trump, Lab. Invest. 1985, 52, 363.
- Protective effects of dithiocarbamates against renal toxicity of cis-diamminedichloroplatinum in rats
- Celecoxib, a selective cyclooxygenase-2 inhibitor, attenuates renal injury in a rat model of Cisplatin-induced nephrotoxicity
- Effect of fructose-1,6-bisphosphate on the nephrotoxicity induced by cisplatin in rats
- Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis
- Cisplatin-induced emesis in the Ferret: a new animal model.
- A. P. Florczyk, J. E. Schurig, W. T. Bradner, Cancer Treat Rep. 1982, 66, 1, 187-189.
- The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential.
- Structure, recognition, and processing of cisplatin-DNA adducts
- Why does cisplatin reach guanine-N7 with competing S-donor ligands available in the cell?
- Biochemical modulation of cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance
- Cisplatin: mode of cytotoxic action and molecular basis of resistance
- Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.
- G. Chu. J. Biol. Chem. 1994, 269, 787.
- Cellular processing of platinum anticancer drugs
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