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CAS RN: 22572-40-3 | Product Number: D5334

1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide Methiodide

Purity: >98.0%(T)
  • EDC Methiodide
  • 1-Ethyl-3-[3-(trimethylammonio)propyl]carbodiimide Iodide
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Product Number D5334
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__9H__2__0IN__3 = 297.18 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic,Heat Sensitive
CAS RN 22572-40-3
Reaxys Registry Number 4162760
PubChem Substance ID 354334709
MDL Number


Appearance White to Almost white powder to crystal
Purity(with Total Nitrogen) min. 95.0 %
Purity(Argentometric Titration) min. 98.0 %
Melting point 95.0 to 99.0 °C
Properties (reference)
Melting Point 97 °C
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
EC Number 245-095-1
Transport Information:
HS Number 2925290090
Condensing Agent


Experimental procedure:
cis-2,3-Diphenylcyclopropane-1-carboxylic acid (~150 mg) is dissolved in dichloromethane (20 mL). 1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide (ETC) (1.1 eq.) and DMAP (0.1 eq.) are added followed by the addition of the chiral amine (1.1 eq.). The mixture is stirred overnight. The solution is washed with deionized water (3 x 5 mL), dried over Na2SO4, concentrated and purified by silica gel column chromatography (hexane/ethyl acetate) to afford the corresponding amide.


PubMed Literature

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