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Published TCIMAIL newest issue No.199
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CAS RN: 536-33-4 | Product Number: E0695
Ethionamide
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Purity: >98.0%(T)
Synonyms:
- 2-Ethylpyridine-4-carbothioamide
- 2-Ethylthioisonicotinamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
€23.00
|
6 | 37 |
|
|
| 25G |
€91.00
|
Contact Us | 24 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | E0695 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__8H__1__0N__2S = 166.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 536-33-4 |
| Reaxys Registry Number | 116474 |
| PubChem Substance ID | 87577933 |
| SDBS (AIST Spectral DB) | 51734 |
| Merck Index (14) | 3737 |
| MDL Number | MFCD00057361 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 160.0 to 164.0 °C |
Properties (reference)
| Melting Point | 162 °C |
| Boiling Point | 167 °C/1 mmHg |
| Solubility (slightly sol. in) | Methanol, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 208-628-9 |
| RTECS# | NS0350000 |
Transport Information:
| HS Number | 2933399999 |
Application
Ethionamide: A Thioamide Anti-Tuberculosis Agent
Ethionamide and prothionamide [P2302] are thioamide anti-tuberculosis agents. They have activity against Mycobacterium tuberculosis, Mycobacterium leprae murium and Mycobacterium avium. The precise mechanisms of action remain unknown, but it has been reported that the thioamides are prodrugs that are oxidatively converted to their active forms by the flavin monooxygenase EtaA of Mycobacterium tuberculosis.
References
- Mechanism of thioamide drug action against tuberculosis and leprosy
- Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases (a review)
- High-performance liquid chromatographic determination of ethionamide and prothionamide in body fluids
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