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CAS RN: 57044-25-4 | Product Number: G0363

(R)-(+)-Glycidol


Purity: >98.0%(GC)
Synonyms:
  • (R)-(+)-1-Hydroxy-2,3-epoxypropane
  • (R)-(+)-2-(Hydroxymethyl)oxirane
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5G
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25G
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1   ≥20 

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Product Number G0363
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__3H__6O__2 = 74.08  
Physical State (20 deg.C) Liquid
Storage Temperature <0°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive,Heat Sensitive
CAS RN 57044-25-4
Reaxys Registry Number 79782
PubChem Substance ID 125307377
MDL Number

MFCD00074873

Specifications
Appearance Colorless to Light yellow clear liquid
Purity(GC) min. 98.0 %
Optical purity(GC) min. 98.0 ee%
Properties (reference)
Boiling Point 57 °C/11 mmHg
Flash point 72 °C
Specific Gravity (20/20) 1.12
Specific Rotation 15° (neat)
Refractive Index 1.43
Solubility in water Completely miscible
GHS
Pictogram Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H331 : Toxic if inhaled.
H302 + H312 : Harmful if swallowed or in contact with skin.
H314 : Causes severe skin burns and eye damage.
H370 : Causes damage to organs.
H373 : May cause damage to organs through prolonged or repeated exposure.
H341 : Suspected of causing genetic defects.
H350 : May cause cancer.
H335 : May cause respiratory irritation.
H360F : May damage fertility.
H242 : Heating may cause a fire.
Precautionary Statements P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P234 : Keep only in original packaging.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
RTECS# RR0508000
Transport Information:
UN Number UN2810
Class 6.1
Packing Group III
HS Number 2910900030
Application
Synthesis of (S)-glycol nucleosides and (S)-phosphoramidites

Typical procedure (Synthesis of the glycol thymine nucleoside (2)): To a solution of (R)-glycidol (1.0 mL) and Et3N (5.4 mL) in CH2Cl2 (34 mL) was added DMTrCl (6.45 g). After 12 h, the reaction mixture was poured into sat. NaHCO3 (50 mL). The organic layer was evaporated; the residue was dissolved in EtOAc, washed with sat. NaHCO3, and purified by silica gel chromatography (elute: hexane/EtOAc/Et3N = 10/1/0.01) to give the DMTr-glycidol (1) as an oil (5.98 g, quant.). A mixture of thymine (0.63 g) and NaH (60 % dispersion in paraffin liquid, 42 mg) in DMF (8 mL) was stirred at rt for 2 h. The DMF (10 mL) solution of the DMTr-glycidol (1) (1.79 g) was added, and the resulting mixture was heated at 110 °C for 20 h. The DMF was evaporated, the residue was extracted with EtOAc, and purified by silica gel chromatography (elute: hexanes/EtOAc/Et3N = 1/2/0.01) to give the glycol thymine nucleoside (2) as a colorless foam (1.22 g, 49 %).

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