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CAS RN: 957-77-7 | Product Number: H1865

5-Hydroxyuridine


Purity: >95.0%(HPLC)(qNMR)
Synonyms:
  • 1-β-D-Ribofuranosylisobarbituric Acid
  • ho5U
  • 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-hydroxypyrimidine-2,4(1H,3H)-dione
Documents:
100MG
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Product Number H1865
Purity / Analysis Method >95.0%(HPLC)(qNMR)
Molecular Formula / Molecular Weight C__9H__1__2N__2O__7 = 260.20 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 957-77-7
Reaxys Registry Number 33666
MDL Number

MFCD00010571

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 95.0 area%
Purity(qNMR) min. 95.0 %
NMR confirm to structure
Properties (reference)
Melting Point 245 °C
Maximum Absorption Wavelength 280(H2O) nm
GHS
Related Laws:
EC Number 213-487-1
Transport Information:
HS Number 2934999090
Application
5-Hydroxyuridine: One of the Oxidized Lesions of Uridine and Cytosine

5-Hydroxyuridine (ho5U) is one of the main lesions of uridine and cytosine produced in RNA by various oxidants.1,2) Oxidized pyrimidines, including 5-hydroxyuridine, are excised from RNA by single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1), a base-excision repair enzyme.3,4) In addition, A highly sensitive detection method for the detection of 5-hydroxyuridine in RNA has been reported.5)

References


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