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Published TCIMAIL newest issue No.199
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CAS RN: 2216-51-5 | Product Number: M0545
(-)-Menthol
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Purity: >99.0%(GC)
Synonyms:
- (-)-p-Menthan-3-ol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
€16.00
|
10 | ≥100 |
|
|
| 100G |
€34.00
|
5 | 35 |
|
|
| 500G |
€120.00
|
1 | 16 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
Synonym: l-Menthol
| Product Number | M0545 |
Purity / Analysis Method 
|
>99.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__0H__2__0O = 156.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 2216-51-5 |
| Reaxys Registry Number | 1902293 |
| PubChem Substance ID | 87572580 |
| SDBS (AIST Spectral DB) | 2543 |
| Merck Index (14) | 5837 |
| MDL Number | MFCD00062979 |
Specifications
| Appearance | White or Colorless powder to crystal |
| Purity(GC) | min. 99.0 % |
| Optical purity(GC) | min. 99.0 ee% |
| Melting point | 42.0 to 45.0 °C |
Properties (reference)
| Melting Point | 43 °C |
| Boiling Point | 216 °C |
| Specific Rotation | -50° (C=10,EtOH) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 490 mg/l 25 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H336 : May cause drowsiness or dizziness. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 218-690-9 |
| RTECS# | OT0700000 |
Transport Information:
| HS Number | 2906110000 |
Application
(-)-Menthol: A Monocyclic Monoterpene Alcohol exhibiting Many Bioactivities
(±)-Menthol [M0321] is a monocyclic monoterpene alcohol found in peppermint which is known to exhibit biological activity such as antibacterial, antifungal, antipruritic, anticancer and analgesic effects. (±)-Menthol is widely used as a product in cosmetics, a flavoring agent, and a synthetic intermediate. (±)-Menthol is a racemic mixture of the (-)-menthol and (+)-menthol [M3170]. (-)-Menthol is more common than (+)-menthol in nature, and exhibits, antibacterial, anticancer, and analgesic properties, as well as inhibits cholinesterase. In contrast, (+)-menthol has antifungal activity, but does not exhibit antibacterial, anticancer, analgesic properties, or cholinesterase inhibitory activities.1) It has been reported that menthol's characteristic pleasant cooling sensation is due to the activation of sensory neurons generally termed transient receptor potential (TRP) channels, in particular transient receptor potential melastatin family member 8 (TRPM8) and transient receptor potential subfamily ankyrin 1 channel (TRPA1).2-4) (The product is for research purpose only.)
References
- 1) Menthol: A simple monoterpene with remarkable biological properties (a review)
- 2) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
- 3) The transient receptor potential channel TRPA1: from gene to pathophysiology (a review)
- 4) TRPA1 (a review)
PubMed Literature
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