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CAS RN: 155648-60-5 | Product Number: M2360

Minodronate Monohydrate


Purity: >98.0%(HPLC)
Synonyms:
  • 1-Hydroxy-2-[imidazo[1,2-a]pyridin-3-yl]ethylidene-1,1-diphosphonic Acid Monohydrate
  • Minodronic Acid Monohydrate
Documents:
25MG
166,00 €
1   9  

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Product Number M2360
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__9H__1__2N__2O__7P__2·H__2O = 340.17 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 155648-60-5
Related CAS RN 180064-38-4
Reaxys Registry Number 19668048
PubChem Substance ID 253660080
MDL Number

MFCD00890772

Specifications
Appearance White to Light yellow to Light red powder to crystal
Purity(HPLC) min. 98.0 area%
NMR confirm to structure
Properties (reference)
Solubility in water Insoluble
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws:
RTECS# SZ8562470
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
HS Number 2933299090
Application
Bone Resorption Inhibitor

M2360

Bisphosphonates (BPs), including minodronate, ibandronate, etc., are very effective inhibitors of bone resorption in vivo and in vitro. Minodronate monohydrate (1) is one of BPs.1,2) These compounds are characterized by two C-P bonds which are located on the same carbon atom, i.e. geminal BPs, and have been used for many research studies regarding bone metabolism.1,2)
According to differences in the side chain, BPs can be divided into two groups, non-nitrogen containing BPs (non-N-BPs) and nitrogen-containing BPs (N-BPs). 1 is a N-BP and is classified as a third-generation heterocyclic N-BP.2,3) N-BPs inhibit farnesyl pyrophosphate synthetase, a key enzyme in the mevalonate pathway, which affects cellular activity and survival.1,2) Regarding inhibition of bone resorption, 1, as well as zoledronic acid, is more effective than other BPs.4)

References


PubMed Literature


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