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CAS RN: 20244-86-4 | Product Number: M3465

7-Methylguanosine


Purity: >85.0%(HPLC)(qNMR)
Synonyms:
  • 2-Amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium
  • 2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium
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200MG
144,00 €
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1G
405,00 €
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Product Number M3465
Purity / Analysis Method >85.0%(HPLC)(qNMR)
Molecular Formula / Molecular Weight C__1__1H__1__5N__5O__5 = 297.27 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 20244-86-4
Reaxys Registry Number 3631436
MDL Number

MFCD16661197

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 85.0 area%
Purity(qNMR) min. 85.0 %
Water max. 11.0 %
Properties (reference)
GHS
Related Laws:
Transport Information:
HS Number 2934999090
Application
RNA aptamer research

Reference


Application
7-Methylguanosine (m7G): The 5' Terminal Cap Structure Present on Eukaryotic mRNA

7-Methylguanosine (m7G) is a purine base modified by the addition of a methyl group and closely resembles the 5' terminal cap structure present on eukaryotic mRNA. The 7-methylguanosine “cap’ is required for the translation of the majority of mRNAs, and it has also been reported to stabilize mRNA against attack by exonucleases and to promote transcription, splicing, polyadenylation and nuclear export of mRNA.1-3) Therefore, efficient mRNA capping enzymatic processes have been studied utilizing 7-methylguanosine.4) In addition, 7-methylguanosine cannot be re-phosphorylated and reused for de novo synthesis, and so is excreted by cells and can be detected in serum and urine. Therefore, it has been used as a biomarker for some types of cancer.5,6) (The product is for research purpose only.)

References


TCIMAIL
Documents (Note: Some products will not have analytical charts available.)
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