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CAS RN: 21829-25-4 | Product Number: N0528

Nifedipine


Purity: >98.0%(E)(HPLC)
Synonyms:
  • 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Dimethyl Ester
Documents:
10G
€58.00
2   ≥40 
25G
€109.00
4   ≥40 

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Product Number N0528
Purity / Analysis Method >98.0%(E)(HPLC)
Molecular Formula / Molecular Weight C__1__7H__1__8N__2O__6 = 346.34 
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 21829-25-4
Reaxys Registry Number 497773
PubChem Substance ID 87573853
SDBS (AIST Spectral DB) 9750
Merck Index (14) 6528
MDL Number

MFCD00057326

Specifications
Appearance Light yellow to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(UV-vis method) min. 98.0 %
Melting point 172.0 to 175.0 °C
Solubility in Acetone almost transparency
Properties (reference)
Melting Point 174 °C
Solubility (soluble in) Acetone,Chloroform
Solubility (very slightly) Ethanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
EC Number 244-598-3
RTECS# US7975000
Transport Information:
HS Number 2933399990
Application
Nifedipine: A Short-Acting Dihydropyridine Calcium Antagonist

Nifedipine is a short-acting dihydropyridine calcium antagonist. It selectively inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle without altering serum calcium concentrations, and induces a relaxation of the muscle. Because of the dilation of resistance vessels, blood pressure falls. Nifedipine is almost completely metabolized by cytochrome P450 3A4 (CYP3A4) in the liver. Nifedipine is a poorly water soluble agent and rapidly metabolized resulting in decreased bioavailability, and then the short-acting can provide increased the risk of stroke et al. Therefore, nifedipine slow-release formulations have been developed. (The product is for research purpose only.)

References


Application
Photobase Generator

References


PubMed Literature


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