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CAS RN: 66085-59-4 | Product Number: N0896

Nimodipine


Purity: >98.0%(HPLC)
Synonyms:
  • Isopropyl 2-Methoxyethyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Documents:
1G
€65.00
1   ≥20 
5G
€225.00
1   ≥20 

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Product Number N0896
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__1H__2__6N__2O__7 = 418.45  
Physical State (20 deg.C) Solid
CAS RN 66085-59-4
Reaxys Registry Number 459792
PubChem Substance ID 135727105
Merck Index (14) 6551
MDL Number

MFCD00153848

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 6.55 to 6.80 %
Melting point 124.0 to 128.0 °C
Properties (reference)
Melting Point 126 °C
Solubility (soluble in) Methanol
GHS
Related Laws:
EC Number 266-127-0
RTECS# US7975500
Transport Information:
HS Number 2933399990
Application
ジヒドロピリジン系のL型Ca2+チャンネルアンタゴニスト,ニモジピン

Nimodipine is a dihydropyridine-derivative L-type Ca2+ channel receptor antagonist which relaxes arterial smooth muscle. It may increase the blood pressure lowering effect of concomitantly administered anti-hypertensive agents. Nimodipine is more lipophilic than nifedipine [N0528], and it crosses the blood-brain barrier and reaches brain and cerebrospinal fluid. Therefore, nimodipine has been shown to dilate cerebral arterioles and increase cerebral blood flow in animals. Nimodipine is mainly metabolized by CYP3A4 in the liver, and its plasma concentration can be significantly increased when concomitantly administered with strong CYP3A4 inhibitors. (The product is for research purpose only.)

References


PubMed Literature


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