Maximum quantity allowed is 999
Please select the quantity
CAS RN: 82752-99-6 | Product Number: N1030
Nefazodone Hydrochloride
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one Hydrochloride
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€23.00
|
1 | 2 |
|
| 1G |
€75.00
|
1 | ≥20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1030 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__3__2ClN__5O__2·HCl = 506.47 |
| Physical State (20 deg.C) | Solid |
| CAS RN | 82752-99-6 |
| Related CAS RN | 83366-66-9 |
| Reaxys Registry Number | 4636943 |
| PubChem Substance ID | 354333934 |
| Merck Index (14) | 6438 |
| MDL Number | MFCD00935760 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
Properties (reference)
| Melting Point | 188 °C |
| Maximum Absorption Wavelength | 248(MeOH) nm |
GHS
Related Laws:
| RTECS# | XZ5483009 |
Transport Information:
| HS Number | 2933599590 |
Application
強力な5-HT2A受容体アンタゴニスト，ネファゾドン塩酸塩
Nefazodone hydrochloride acts as a potent antagonist at the postsynaptic serotonin (5-hydroxytryptamine [S0370]; 5-HT) 5-HT2A receptors, and moderately inhibits serotonin and noradrenaline (norepinephrine) [A0906] reuptake. According to in vitro binding studies, nefazodone has no significant affinity for the following receptors: α2- and β-adrenergic, 5-HT1A, cholinergic, dopaminergic, or benzodiazepine. Nefazodone hydrochloride used to use as a synthetically derived phenylpiperazine antidepressant, but was withdrawn from the world pharmaceutical market in 2000s due to its hepatotoxicity. (The product is for research purpose only.)
References
- Nefazodone: preclinical pharmacology of a new antidepressant
- Nefazodone, A review of its pharmacology and clinical efficacy in the management of major depression
- Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4
- In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone
- Rapid and simple methods for quantitative analysis of some antidepressant in pharmaceutical formulations by using first derivative spectrophotometry and HPLC
PubMed Literature
Articles/Brochures
TCIMAIL
Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number is entered
Analytical Charts
Please enter Lot Number
Incorrect Lot Number is entered
The requested analytical chart is not available. Sorry for the inconvenience.