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CAS RN: 82752-99-6 | Product Number: N1030

Nefazodone Hydrochloride

Purity: >98.0%(T)(HPLC)
  • 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one Hydrochloride
1   2  
1   ≥20 

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Product Number N1030
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__5H__3__2ClN__5O__2·HCl = 506.47  
Physical State (20 deg.C) Solid
CAS RN 82752-99-6
Related CAS RN 83366-66-9
Reaxys Registry Number 4636943
PubChem Substance ID 354333934
Merck Index (14) 6438
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 186.0 to 190.0 °C
Properties (reference)
Melting Point 188 °C
Maximum Absorption Wavelength 248(MeOH) nm
Related Laws:
RTECS# XZ5483009
Transport Information:
HS Number 2933599590

Nefazodone hydrochloride acts as a potent antagonist at the postsynaptic serotonin (5-hydroxytryptamine [S0370]; 5-HT) 5-HT2A receptors, and moderately inhibits serotonin and noradrenaline (norepinephrine) [A0906] reuptake. According to in vitro binding studies, nefazodone has no significant affinity for the following receptors: α2- and β-adrenergic, 5-HT1A, cholinergic, dopaminergic, or benzodiazepine. Nefazodone hydrochloride used to use as a synthetically derived phenylpiperazine antidepressant, but was withdrawn from the world pharmaceutical market in 2000s due to its hepatotoxicity. (The product is for research purpose only.)


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