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CAS RN: 548472-68-0 | Product Number: N1195
Nutlin-3
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Purity: >95.0%(HPLC)
Synonyms:
- rel-4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€101.00
|
Contact Us | 20 |
|
| 50MG |
€347.00
|
Contact Us | 26 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1195 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__0H__3__0Cl__2N__4O__4 = 581.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 548472-68-0 |
| PubChem Substance ID | 468592509 |
| MDL Number | MFCD07784509 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation | -1.0 to +1.0 deg(C=0.2, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2933599590 |
Application
Nutilin-3: A Small-Molecule Inhibitor of MDM2-P53 Protein-Protein Interaction
Tumor suppress protein p53 is an attractive target for cancer research because it can be functionally activated to eradicate tumors. Mouse double minute 2 homolog (MDM2) is a protein found in many human tumors, and binds the p53 with high affinity and negative modulates p53 transcriptional activity and stability. Nutilin-3 is a small-molecule inhibitor of MDM2-p53 protein-protein interaction. Nutilin-3 binds MDM2 in the p53-binding pocket and activate the p53 pathway in tumor cells, leading to cell cycle arrest, apoptosis, and growth inhibition of tumor cells. (The product is for research purpose only.)
References
- In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
- Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
- Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy (a review)
- Recent advances in the therapeutic perspectives of nutlin-3 (a review)
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