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Published TCIMAIL newest issue No.198
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CAS RN: 641571-10-0 | Product Number: N1296
Nilotinib
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Purity: >95.0%(T)(HPLC)
Synonyms:
- 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€125.00
|
Contact Us | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1296 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__2__2F__3N__7O = 529.53 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 641571-10-0 |
| Reaxys Registry Number | 10737140 |
| MDL Number | MFCD09833716 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 236.0 to 240.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 238 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P273 : Avoid release to the environment. P260 : Do not breathe dust. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| RTECS# | CV5581770 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| HS Number | 2933599590 |
Application
Nilotinib: A BCR-ABL Tyrosine Kinase Inhibitor
Nilotinib (AMN107) is a BCR-ABL tyrosine kinase inhibitor. Nilotinib binds to and stabilizes the inactive conformation of the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib [I0906] [I0936 (mesylate)]. In vitro, nilotinib inhibited BCR-ABL-mediated proliferation of murine leukemia cell lines. (The product is for research use only.)
References
- Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
- AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL (a review)
- Nilotinib : A Novel, Selective Tyrosine Kinase Inhibitor (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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