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Published TCIMAIL newest issue No.198
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CAS RN: 212631-79-3 | Product Number: P2174
PD 184352
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Purity: >98.0%(HPLC)
Synonyms:
- 2-(2-Chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
157,00 €
|
Contact Us | 8 |
|
| 100MG |
422,00 €
|
Contact Us | 12 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2174 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__4ClF__2IN__2O__2 = 478.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 212631-79-3 |
| Reaxys Registry Number | 10032343 |
| PubChem Substance ID | 468592581 |
| MDL Number | MFCD02683961 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.30 to 6.30 % |
| Melting point | 176.0 to 180.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 178 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2928009090 |
Application
PD184352: A Selective Inhibitor of Mitogen-Activated Protein Kinase (MAPK)
PD184352 (or Cl-1040) is an orally active and selective inhibitor of mitogen-activated protein kinase (MAPK or MAP kinase), a type of serine/threonine protein kinase.
References
- Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
- Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia
- CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK) (a review)
- The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (Cl-1040) selectively induces apoptosis in malignant schwannoma cell lines
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Analytical Charts
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Other Documents
Related Products
![PD 184352 [Optimized for Cell Culture]](/medias/Tci-300-P3157.jpg?context=bWFzdGVyfHJvb3R8MTE5MzZ8aW1hZ2UvanBlZ3xhRGhpTDJnNVpTODVOVEF6TURBM09EQXhNemMwTDFSamFTMHpNREJmVURNeE5UY3VhbkJufGE1YWZkMDhiY2E1MGQ3NGE3MmQxYmYyMmQ3OTIyOTdiNzAxMWQ0YzgyNTBmZjIyZjUyMWIyNWRmMTJmMDI4ZTQ "PD 184352 [Optimized for Cell Culture]")
PD 184352 [Optimized for Cell Culture]
| Product # | P3157 |
| CAS RN | 212631-79-3 |
| Purity / Analysis Method: |