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Published TCIMAIL newest issue No.199
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CAS RN: 566-65-4 | Product Number: P2423
5α-Pregnane-3,20-dione
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Purity: >98.0%(GC)
Synonyms:
- 3,20-Allopregnanedione
- 5α-Dihydroprogesterone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€63.00
|
1 | 31 |
|
|
| 5G |
€218.00
|
2 | 7 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P2423 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__1H__3__2O__2 = 316.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 566-65-4 |
| Reaxys Registry Number | 2058506 |
| PubChem Substance ID | 468592596 |
| Merck Index (14) | 272 |
| MDL Number | MFCD00067132 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 202.0 to 206.0 °C |
| Specific rotation [a]20/D | 113 to 123 deg(C=1, CHCL3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 204 °C |
| Specific Rotation | 118° (C=1,CHCl3) |
GHS
Related Laws:
| EC Number | 209-297-3 |
| RTECS# | TU4157150 |
Transport Information:
| HS Number | 2937290000 |
Application
5α-Pregnane-3,20-dione (5α-DHP): An Endogenous Neurosteroid
5α-Pregnane-3,20-dione (5α-DHP) is an endogenous progestogen and neurosteroid that is synthesized from progesterone [P0478] in the central and peripheral nervous system. 5α-DHP is also actively metabolized into neuroactive steroid metabolites, such as allopregnanolone and isopregnanolone. In addition, 5α-DHP is reported to act as a potent positive allosteric modulator of the action of γ-aminobutyric acid (GABA) at GABAA receptor.
References
- Neurosteroids: 3α-Hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats
- Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions (a review)
- Progesterone and allopregnanolone in the central nervous system: Response to injury and implication for neuroprotection (a review)
- Gas chromatographic-mass fragmentographic quantitation of 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats
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