Quetiapine Hemifumarate: A Multi-Acting Receptor Targeted Antipsychotic (MARTA)
Quetiapine hemifumarate is known as a multi-acting receptor targeted antipsychotic (MARTA), such as clozapine [
C2547] and olanzapine [
O0393]. Quetiapine has greater affinity for serotonin 5-HT
2A and dopamine D
1 and D
2 receptors. Furthemore, quetiapine has various affinities for multiple receptors, including 5-HT
1A and α
1- and α
2-adrenergic receptors. While, quetiapine binds weakly to benzodiazepine (BZD) and muscarinergic M
1A receptors. The precise mechanism of action is unknown, but quetiapine is used as a thienobenzodiazepine atypical antipsychotic. (The product is for research purpose only.)