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CAS RN: 599-79-1 | Product Number: S0580


Purity: >95.0%(T)(HPLC)
  • 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic Acid
2   ≥20 

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Product Number S0580
Purity / Analysis Method >95.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__8H__1__4N__4O__5S = 398.39  
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 599-79-1
Reaxys Registry Number 356241
PubChem Substance ID 87560165
Merck Index (14) 8942
MDL Number


Appearance Light yellow to Amber to Dark green powder to crystal
Purity(HPLC) min. 95.0 area%
Purity(Neutralization titration) min. 95.0 %
Properties (reference)
Melting Point 246 °C(dec.)
Solubility in water Insoluble
Solubility (slightly sol. in) Alcohol
Solubility (insoluble in) Ether,Benzene,Chloroform
Pictogram Pictogram
Signal Word Warning
Hazard Statements H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
EC Number 209-974-3
RTECS# VO6250000
Transport Information:
HS Number 2935909099
Sulfasalazine: A Prodrug of 5-Aminosalicylic Acid (5-ASA), a NF-κB Inhibitor and an xCT Inhibitor

Sulfasalazine (salazosulfapyridin) is formed by combining sulfapyridine and salicylate with an azo bond. Sulfasalazine is split by intestinal bacteria to two main matabolites, sulfapyridine [S0071] and 5-aminosalicylic acid (5-ASA) [A0317], and the 5-ASA shows anti-inflammatory effects. Sulfasalazine is used as a gastrointestinal anti-inflammatory agent and is known as a potent inhibitor of NF-κB. Sulfasalazine is commonly used in the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease (CD) and rheumatoid arthritis (RA).
Recently, the antitumor effects of sulfasalazine have attracted attention. CD44v is an adhesion molecule expressed in cancer stem-like cells. CD44v interacts with xCT, a glutamate-cysteine transporter, keeping high levels of the intracellular reduced glutathione (GSH) which an important antioxidant and stabilizer in cell. Sulfasalazine works as an xCT inhibitor, and suppresses CD44v-dependent tumor growth and increases sensitivity to cytotoxic drugs. (The product is for research purpose only.)


PubMed Literature

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