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CAS RN: 36635-61-7 | Product Number: T1046

p-Toluenesulfonylmethyl Isocyanide

Purity: >98.0%(HPLC)(N)
  • TosMIC
  • Tosylmethyl Isocyanide
€ 26,00
2   ≥40 
€ 91,00
5   ≥40 

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Product Number T1046
Purity / Analysis Method >98.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__9H__9NO__2S = 195.24 
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
CAS RN 36635-61-7
Reaxys Registry Number 2331606
PubChem Substance ID 87576847
SDBS (AIST Spectral DB) 15758
Merck Index (14) 9556
MDL Number


Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Properties (reference)
Melting Point 110 °C
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
EC Number 253-140-1
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
HS Number 2930909831
Synthesis of Heterocyclic Compounds using TosMIC (Multicomponent Reactions)

Typical Procedure (Entry 3):
To a stirred solution of o-phenylenediamine (1.0 mmol) in toluene (20 mL), 4-chlorobenzaldehyde (1.0 mmol) is added and stirring is continued for 5 min. Then TosMIC (1.0 mmol) and DABCO (1.2 mmol) are added and the reaction mixture is heated to 80 °C for 4 h. The resulting solution is initially washed with 5% HCl, then with H2O and dried. The solvent is distilled off under reduced pressure to yield the corresponding crude product mixture, which is purified by silica gel chromatography (petroleum ether : EtOAc = 10 : 1) as eluent, to give the desired quinoxaline derivative in 84% yield as yellow crystals.


Carbon Homologation Reaction (Ketones → One-carbon homologated nitriles)


PubMed Literature

Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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C of A & Other Certificates
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Other Documents

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