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CAS RN: 60239-18-1 | Product Number: T1875
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid
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Purity: >97.0%(T)
Synonyms:
- DOTA
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€119.00
|
Contact Us | ≥20 |
|
| 1G |
€415.00
|
Contact Us | ≥20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T1875 |
| Purity / Analysis Method | >97.0%(T) |
| Molecular Formula / Molecular Weight | C__1__6H__2__8N__4O__8 = 404.42 |
| Physical State (20 deg.C) | Solid |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 60239-18-1 |
| Reaxys Registry Number | 1186987 |
| PubChem Substance ID | 87560717 |
| MDL Number | MFCD00068657 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(Chelometric Titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 267 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
The Reviews of DOTA: One of the Preeminent Carriers of Metal-Based Imaging Contrast Agents for Biomedical Imaging.
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is one of the preeminent carriers of metal-based imaging contrast agents. Metal complexes of DOTA-peptide or others conjugates have increasingly used in Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT) and Fluorescence imaging.
References
- The Synthesis and Chelation Chemistry of DOTA-Peptide Conjugates
- PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics
- 64Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor αvβ3 integrin expression
- The coordination chemistry of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (H4DOTA): Structural overview and analyses on structure-stability relationships
- The ubiquitous DOTA and its derivatives: the impact of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid on biomedical imaging
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