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CAS RN: 19542-67-7 | Product Number: T2846
BAY 11-7082
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Purity: >98.0%(HPLC)(N)
Synonyms:
- (E)-3-Tosylacrylonitrile
- (E)-3-(p-Toluenesulfonyl)acrylonitrile
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
78,00 €
|
Contact Us | ≥80 |
|
| 1G |
489,00 €
|
Contact Us | 27 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2846 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__0H__9NO__2S = 207.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 19542-67-7 |
| Reaxys Registry Number | 2049371 |
| PubChem Substance ID | 135727354 |
| MDL Number | MFCD00712162 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 132.0 to 136.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 134 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UD1430000 |
Transport Information:
| HS Number | 2926907090 |
Application
Bay 11-7082: An Inhibitor of NFκB and IκBα Phosphorylation
Bay 11-7082 and Bay 11-7085 [B4845] are inhibitors of nuclear factor-κB (NFκB) and phosphorylation of IκBα. They have been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. NFκB is a protein complex controls transcription of DNA and inflammatory cytokine production. Researches demonstrate that inhibition of NFκB can suppress the angiogenic potential and metastasis of cancer cells. IκBα is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. In addition, they have anti-inflammatory activity.
References
- Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
- Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I–infected T-cell lines andκprimary adult T-cell leukemia cells
- Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
- Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
- The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells
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