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CAS RN: 91161-71-6 | Product Number: T3677
Terbinafine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine
- (E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€53.00
|
1 | 7 |
|
| 5G |
€175.00
|
2 | 20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3677 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__5N = 291.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 91161-71-6 |
| Related CAS RN
|
78628-80-5 |
| Reaxys Registry Number | 4256376 |
| PubChem Substance ID | 468592889 |
| Merck Index (14) | 9156 |
| MDL Number | MFCD00242672 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 41.0 to 45.0 °C |
Properties (reference)
| Melting Point | 43 °C |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
| RTECS# | QJ8600000 |
Transport Information:
| HS Number | 2941900000 |
Application
Terbinafine: A Potent Non-Competitive Inhibitor of Squalene Epoxidase
Terbinafine and its hydrochloride [D2049], allylamine antifungals, are potent non-competitive inhibitors of fungal squalene epoxidase, a key enzyme in ergosterol biosynthesis. Ergosterol is an essential component of fungal cell membrane, and terbinafine inhibits ergosterol synthesis at the stage of squalene epoxidation. This results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not due to ergosterol deficiency. (The product is for research purpose only.)
References
- Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase
- The mechanism of action of terbinafine
- Clinical pharmacokinetics of terbinafine (Lamisil)
- Terbinafine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial mycoses
- Terbinafine: a pharmacological and clinical review
- Determination of terbinafine in tissues
- Rapid UHPLC method for simultaneous determination of vancomycin, terbinafine, spironolactone, furosemide and their metabolites: application to human plasma and urine
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