Venlafaxine Hydrochloride: A Serotonin/Norepinephrine Reuptake Inhibitor (SNRI)
Venlafaxine hydrochloride belongs to a serotonin [
S0370] /norepinephrine [
A0906] reuptake inhibitors (SNRIs). Studies have shown that venlafaxine and its active metabolite,
O-desmethylvenlafaxine (ODV) [
D5598], are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine [
A0305] reuptake. Venlafaxine and ODV have no significant affinity for muscarinic cholinergic, H
1-histaminergic, or α
1-adrenergic receptors
in vitro. For your reference, duloxetine hydrochloride [
D4223] and milnacipran hydrochloride [
M2133] also belong to SNRIs. (The product is for research purpose only.)