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Published TCIMAIL newest issue No.198
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Divinyl Sulfone, a Useful Cross-linking Agent
Advantages
- Two electron-deficient vinyl groups are useful to form chemical bonds between a variety of molecules.
- Many years of manufacturing experience.
- Available in large quantities.
Applications
Agarose gel activation for immobilization of enzymes and proteins 1,2)
Divinyl sulfone is used for immobilization of enzymes and proteins because vinyl sulfone groups can react with amino, phenol, imidazole, and thiol groups.
Cross-linking of hyaluronic acid 3)
Cross-linking with divinyl sulfone is used to modify the mechanical properties and degradation rate of hyaluronic acid hydrogels in research aimed at applications such as regenerative medicine.
Cross-linking of a conductive polymer PEDOT:PSS 4)
In the bioelectronics research including wearable sensors, cross-linking with divinyl sulfone is used to improve the stability of PEDOT:PSS in water or its bonding with other materials while maintaining the conductivity and flexibility of PEDOT:PSS.
Electrolyte additive for batteries 5)
Divinyl sulfone has been reported to enhance the cathode-electrolyte interfacial stability in lithium-ion batteries with Ni-rich cathodes by forming a passivation layer derived from divinyl sulfone on the cathode surface.
References
- 1) Characterization of supports activated with divinyl sulfone as a tool to immobilize and stabilize enzymes via multipoint covalent attachment. Application to chymotrypsin
- 2) Stabilization of enzymes via immobilization: Multipoint covalent attachment and other stabilization strategies
- 3) From crosslinking strategies to biomedical applications of hyaluronic acid-based hydrogels: A review
- 4) PEDOT:PSS-modified cotton conductive thread for mass manufacturing of textile-based electrical wearable sensors by computerized embroidery
- 5) Understanding the effects of a multi-functionalized additive on the cathode–electrolyte interfacial stability of Ni-rich materials
