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Published TCIMAIL newest issue No.198
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Reagents for Introduction of the Teoc-Protecting Group
No.145(March 2012)
The Teoc-protecting group is one possible protecting group for amines. It is cleaved with the fluoride ion. 1 and 2 are used with a base such as triethylamine. Impurities from leaving groups are removed by washing with water or aqueous sodium bicarbonate. 3 is a novel reagent for the introduction of the Teoc-protecting group. Its high activity enables it to react with hindered amines. The by-product nitrotriazole has low solubility in dichloromethane and can be removed by simple filtration. Complicated compounds can be synthesized efficiently by using a Teoc-protecting group and other protecting groups according to your needs.
References
- 1)Introduction of the Teoc-protecting group using Teoc-OSu or Teoc-OBt
- 2)Introduction of the Teoc-protecting group using Teoc-NT
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