Carbohydrate chains are called the third life chain following the protein and the nucleic acid and are one of the most important issues in the post genome research. We support glycoscience research by providing useful anti-carbohydrate chain antibodies.
Most carbohydrate chains attach to lipids or proteins and occur in the form of glycoproteins or glycolipids (N-glycan, O-glycan, proteoglycans and others). Carbohydrate chains are known to be expressed on brain, nerve, cancer, and endothelial cells. Some carbohydrate chains are known to relate to diseases (e.g., cancer, Alzheimer's disease, Guillain-Barré syndrome, Lysosome syndrome such as Fabry disease, gangliosidosis), differentiation and development (iPS/ES cells). Seasonal influenza viruses, annual epidemics that peak during winter, cause infection via cell-surface glycans. Anti-influenza virus drugs are structural mimics of sialic acid, because neuraminidase is a sialic acid hydrolase that is essential for the release of progeny virus particles from the surface of an infected cell.
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