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CAS RN: 9041-93-4 | Product Number: B3972

Bleomycin Sulfate (mixture)


Purity: >85.0%(HPLC)
Synonyms:
Documents:
10MG
€79.00
1   ≥20 
50MG
€296.00
2   ≥20 

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Product Number B3972
Purity / Analysis Method >85.0%(HPLC)
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic,Heat Sensitive
CAS RN 9041-93-4
Related CAS RN 11056-06-7
PubChem Substance ID 253659941
Merck Index (14) 1318
MDL Number

MFCD00070310

Specifications
Appearance White to Orange to Green powder to crystaline
Purity(HPLC) min.85.0 area% (Sum of A2,B2)
BleomycinA2 55.0 to 70.0 area%
BleomycinB2 25.0 to 32.0 area%
Properties (reference)
Solubility in water Completely soluble
Solubility (very slightly) Ethanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 232-925-2
RTECS# EC5991990
Transport Information:
HS Number 2941900000
Application
Reagent for pneumonitis model
References

Effect of lecithinized-superoxide dismutase on the interstitial pneumonia model induced by bleomycin in mice

C. Yamazaki, J. Hoshino, Y. Hori, T. Sekiguchi, S. Miyauchi, S. Mizuno, K. Horie, Jpn. J. Pharmacol. 1997, 75, 97.

Regulation of type II alveolar epithelial cell proliferation by TGF-beta during bleomycin-induced lung injury in rats

N. Khalil, R. N. O'Connor, K. C. Flanders, W. Shing, C. I. Whitman, Am. J. Physiol. 1994, 267, 498.

Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model

C. Yamazaki, J. Hoshino, T. Sekiguchi, Y. Hori, S. Miyauchi, S. Mizuno, K. Horie, Jpn. J. Pharmacol. 1998, 78, 69.

Dual effect of AMD3100, a CXCR4 antagonist, on bleomycin-induced lung inflammation

M. Watanabe, W. Matsuyama, Y. Shirahama, H. Mitsuyama, K. Oonakahara, S. Noma, I. Higashimoto, M. Osame, K. Arimura, J. Immunol. 2007, 178, 5888.

Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model

N. I. Chaudhary, A. Schnapp, J. E. Park, Am. J. Respir. Crit. Care Med. 2006, 173, 769.

In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats

A. Serrano-Mollar, D. Closa, N. Prats, S. Blesa, M. Martinez-Losa, J. Cortijo, J. M. Estrela, E. J. Morcillo, O. Bulbena, Br. J. Pharmacol. 2003, 138, 1037.

Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice

S. Udalov, R. Dumitrascu, S. S. Pullamsetti, H. M. Al-tamari, N. Weissmann, H. A. Ghofrani, A. Guenther, R. Voswinckel, W. Seeger, F. Grimminger, R. T. Schermuly, BMC Pulm. Med. 2010, 10, 26.


Application
Reagent for pulmonary fibrosis model
References

Modeling pulmonary fibrosis with bleomycin

M. A. Mouratis, V. Aidinis, Curr. Opin. Pulm. Med. 2011, 17, 355.

Pulmonary fibrosis: searching for model answers

F. Chua, J. Gauldie, G. J. Laurent, Am. J. Respir. Cell Mol. Biol. 2005, 33, 9.


Application
Bleomycin: A Glycopeptide Antitumor Antibiotics Agent

Bleomycin, a glycopeptide antitumor antibiotic agent, was first discovered in 1966 when the Japanese bacteriologist Umezawa found anticancer activity while screening culture filtrates of Streptomyces verticillus. Activated bleomycin (Fe-bleomycin-O2 complex), the active species, forms in the reaction of bleomycin with Fe(II) and O2. It also forms in the reaction of bleomycin with Fe(III) and peroxide, or bleomycin with superoxide and either Fe(III) or Fe(II). The activated bleomycin produces DNA strand break at 3'-4' bond in a deoxyribose sugar moiety. The mechanism of this bond cleavage reaction and the nature of the active oxidizing species are still open issues.

References


PubMed Literature


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