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CAS RN: 65391-42-6 | Product Number: B4000

Ubenimex Hydrochloride [for Biochemical Research]


Purity: >97.0%(HPLC)
Synonyms:
  • N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride
Documents:
25MG
€197.00
3   12  

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number B4000
Purity / Analysis Method >97.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__2__4N__2O__4·HCl = 344.84  
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 65391-42-6
Related CAS RN 58970-76-6
Reaxys Registry Number 5840390
PubChem Substance ID 253659625
MDL Number

MFCD00058004

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 97.0 area%
Elemental analysis(Nitrogen) 7.80 to 8.40 %
Specific rotation [a]20/D -12.0 to -14.0 deg(C=0.5、HCl)
Functionality test to pass test
Properties (reference)
Melting Point 108 °C(dec.)
Specific Rotation -13° (C=0.5,1mol/L HCl)
GHS
Related Laws: / Compliance with laws, Regulations
Transport Information:
HS Number 2924297099
Application
Aminopeptidase B Inhibitor
References

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis

R. Pasqualini, E. Koivunen, R. Kain, J. Lahdenranta, M. Sakamoto, A. Stryhn, R. A. Ashmun, L. H. Shapiro, W. Arap, E. Ruoslahti, Cancer Res. 2000, 60, 722.

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes

H. Umezawa, T. Aoyagi, H. Suda, M. Hamada, T. Takeuchi, J. Antibiot. 1976, 29, 97.

Bestatin-mediated inhibition of leucine aminopeptidase may hinder HIV infection

G. Pulido-Cejudo, B. Conway, P. Proulx, R. Brown, C. A. Izaguirre, Antiviral Res. 1997, 36, 167.

Leucine aminopeptidase: bestatin inhibition and a model for enzyme-catalyzed peptide hydrolysis

S. K. Burley, P. R. David, W. N. Lipscomb, Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 6916.

Inhibition of aminopeptidases N, A and W: A re-evaluation of the actions of bestatin and inhibitors of angiotensin converting enzyme

S. Tieku, N. M. Hooper, Biochem. Pharmacol. 1992, 44, 1725.


PubMed Literature


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