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CAS RN: 144060-53-7 | Product Number: F0847

Febuxostat


Purity: >97.0%(T)(HPLC)
Synonyms:
  • 2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic Acid
Documents:
1G
€15.00
3   ≥20 
5G
€43.00
1   ≥20 

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number F0847
Purity / Analysis Method >97.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__6H__1__6N__2O__3S = 316.38  
Physical State (20 deg.C) Solid
CAS RN 144060-53-7
Reaxys Registry Number 8005333
PubChem Substance ID 172089002
Merck Index (14) 3948
MDL Number

MFCD00871598

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Neutralization titration) min. 97.0 %
Melting point 207.0 to 211.0 °C
Properties (reference)
Melting Point 209 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
Related Laws: / Compliance with laws, Regulations
RTECS# XJ3675310
Transport Information:
HS Number 2934100090
Application
Studies on the Inhibition of Xanthine Oxidoreductase, Febuxostat
References

An Extremely Potent Inhibitor of Xanthine Oxidoreductase

K. Okamoto, B. T. Eger, T. Nishino, S. Kondo, E. F. Pai, T. Nishino, J. Biol. Chem. 2003, 278, 1848.

Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase

Y. Takano, K. Hase-Aoki, H Horiuchi, L. Zhao, Y. Kasahara, S. Kondo, M. A. Becker, Life Sci. 2005, 76, 1835.

Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents

Y. Osada, M. Tsuchimoto, H. Fukushima, K. Takahashi, S. Kondo, M. Hasegawa, K. Komoriya, Eur. J. Pharmacol. 1993, 241, 183.

Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome

L. G. Sánchez-Lozada, E. Tapia, P. Bautista-García, V. Soto, C. Ávila-Casado, I. P. Vega-Campos, T. Nakagawa, L. Zhao, M. Franco, R. J. Johnson, Am. J. Physiol. 2008, 294, F710.


PubMed Literature


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