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CAS RN: 126-07-8 | Product Number: G0384

(+)-Griseofulvin


Purity: >97.0%(HPLC)
Synonyms:
Documents:
5G
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25G
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Product Number G0384
Purity / Analysis Method >97.0%(HPLC)
Molecular Formula / Molecular Weight C__1__7H__1__7ClO__6 = 352.77  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 126-07-8
Reaxys Registry Number 95226
PubChem Substance ID 135727206
Merck Index (14) 4549
MDL Number

MFCD00082343

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Argentmetric Titration) min. 95.0 %
Melting point 218.0 to 222.0 °C
Specific rotation [a]20/D +350.0 to +364.0 deg(C=1, DMF)
Properties (reference)
Melting Point 220 °C
Specific Rotation 360° (C=1,DMF)
Maximum Absorption Wavelength 321(CHCl3) nm
Solubility in water Insoluble
Solubility (soluble in) Dimethylformamide
Solubility (slightly sol. in) Methanol,Chloroform,Acetone,Ethanol
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H360 : May damage fertility or the unborn child.
H371 : May cause damage to organs.
H373 : May cause damage to organs through prolonged or repeated exposure.
H340 : May cause genetic defects.
H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 204-767-4
RTECS# WG9800000
Transport Information:
HS Number 2941900000
Application
Studies on Antifungal Activity
References

Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines

A. Amal Raja, R. Raghunathana, M. R. SrideviKumarib, N. Raman, Bioorg. Med. Chem. 2003, 11, 407.


Application
Preparation of Griseofulvin Nanoparticles
References

Production of antibiotic micro- and nano-particles by supercritical antisolvent precipitation

E. Reverchon, G. Della Porta, Powder Technol. 1999, 106, 23.

Production of griseofulvin nanoparticles using supercritical CO2 antisolvent with enhanced mass transfer

P. Chattopadhyay, R. B. Gupta, Int. J. Pharm. 2001, 228, 19.

Preparation of griseofulvin nanoparticles from water-dilutable microemulsions

M. Trotta, M. Gallarate, M. E. Carlotti, S. Morel, Int. J. Pharm. 2003, 254, 235.

Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin

W. L. Chiou, S. Riegelman, J. Pharm. Sci. 1969, 58, 1505.


PubMed Literature


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