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CAS RN: 383418-30-2 | Product Number: H1553

HPA-12


Purity: >98.0%(HPLC)
Synonyms:
  • N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
  • N-[(2R,4S)-1,4-Dihydroxy-4-phenylbutan-2-yl]dodecanamide
Documents:
5MG
€334.00
6   ≥20 

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Product Number H1553
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__2H__3__7NO__3 = 363.54  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 383418-30-2
Reaxys Registry Number 9011453
PubChem Substance ID 354333350
Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 3.60 to 4.10 %
Properties (reference)
Specific Rotation -38.9° (C=0.36,CHCl3)
GHS
Related Laws: / Compliance with laws, Regulations
Transport Information:
HS Number 2924297099
Application
HPA-12: An Important Ceramide-Trafficking Inhibitor

H1553

HPA-12 is a ceramide (Cer) -trafficking inhibitor that was first discovered and synthesized by Hanada and Kobayashi et al.1-3) Ceramide is synthesized in the endoplasmic reticulum (ER) and is transported to the Golgi apparatus, where it is converted to sphingomyelin, by means of the ceramide transport protein (CERT). HPA-12 inhibits the CERT,6) and has been used as a CERT inhibitor in various biological science studies.7-12) For example, HPA-12 possesses antiviral and antibacterial properties against the growth of hepatitis C virus (HCV) and the obligate intracellular bacteria Chlamydiae in cultured human cells.7,10,11) In addition, the CERT inhibition results in resensitization of cancer cells to chemotherapeutic agents such as paclitaxel [ P1632].8) Meanwhile, a point mutation of CERT gene, which dysregulates the function of CERT,14) causes a mental retardation disorder with autosomal dominant inheritance.13) Therefore, inhibition of CERT may represent medical strategies, such as anti-infective and anticancer chemotherapy. (The product is for research purpose only.)

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