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CAS RN: 136572-09-3 | Product Number: I0714

Irinotecan Hydrochloride Trihydrate

Purity: >98.0%(T)(HPLC)
  • CPT-11 Trihydrate
5   ≥20 

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Product Number I0714
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__3__3H__3__8N__4O__6·HCl·3H__2O = 677.2  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 136572-09-3
Related CAS RN 100286-90-6&97682-44-5
Reaxys Registry Number 4838283
PubChem Substance ID 87560270
Merck Index (14) 5091
MDL Number


Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +22.0 to +26.0 deg(C=1, methanol)
Water 7.0 to 10.0 %
Properties (reference)
Boiling Point 257 °C
Specific Rotation 24° (C=1,MeOH)
Solubility (soluble in) Methanol
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H372 : Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P314 : Get medical advice/ attention if you feel unwell.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws: / Compliance with laws, Regulations
RTECS# DW1060750
Transport Information:
HS Number 2933998090
Irinotecan hydrochloride (CPT-11): A Water Soluble Topoisomerase-I Inhibitor with Enhanced Activity

Irinotecan hydrochloride (CPT-11) is a derivative of 7-ethylcamptothecin (SN-22) [E0781] or Camptothecin (CPT) [C1495]. Irinotecan hydrochloride has greater water solubility and enhanced topoisomerase-I inhibitory activity than theirs. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) [E0748] by a carboxylesterase-converting enzyme. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death. (The product is for research purpose only.)


PubMed Literature

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