text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 50-07-7 | Product Number: M2320

Ametycin


Purity: >98.0%(HPLC)
Synonyms:
  • Mitomycin C
Documents:
10MG
€61.00
Contact Us ≥20 
50MG
€212.00
1   ≥20 

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number M2320
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__5H__1__8N__4O__5 = 334.33  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 50-07-7
Reaxys Registry Number 3570056
PubChem Substance ID 172088986
Merck Index (14) 6215
MDL Number

MFCD00078109

Specifications
Appearance Dark red to Dark purple to Dark blue powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 16.4 to 17.0 %
Properties (reference)
Melting Point 64 °C
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 200-008-6
RTECS# CN0700000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group II
HS Number 2941900000
Application
Ametycin: A DNA Interstrand Cross-Linking Agent

Ametycin (also known as Mitomycin C) is an antitumor antibiotic and a bifunctional alkylating agent, first isolated from the broth filtrate of Streptomyces caespitosus by Hata et al. (Kitasato Institute) in 1955. Some metabolic activation forms of ametycin inhibit DNA synthesis by causing cross-linking specificity for the sequence CpG. Ametycin causes cell cycle arrest in phase-nonspecific but is most active in S and G phases, and induces apoptosis in cancer cells.

References


PubMed Literature


TCIMAIL
Documents
Safety Data Sheet (SDS) Search
Please select Language.

The requested SDS is not available.

• Please check that the Product Number you have entered is correct.

• If your information is correct and you are still not able to view the requested SDS,  please Contact Us for more information.

C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number is entered
Other Documents