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CAS RN: 114-80-7 | Product Number: N0358

Neostigmine Bromide


Purity: >99.0%(T)
Synonyms:
  • (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide
  • (3-Hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate
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Product Number N0358
Purity / Analysis Method >99.0%(T)
Molecular Formula / Molecular Weight C__1__2H__1__9BrN__2O__2 = 303.2  
Physical State (20 deg.C) Solid
Condition to Avoid Hygroscopic
CAS RN 114-80-7
Related CAS RN 59-99-4
Reaxys Registry Number 3640678
PubChem Substance ID 87573710
SDBS (AIST Spectral DB) 5015
Merck Index (14) 6464
MDL Number

MFCD00011795

Specifications
Appearance White to Almost white powder to crystal
Purity(Nonaqueous Titration) min. 99.0 %(after drying)
Solubility in Water almost transparency
Drying loss max. 1.0 %
Properties (reference)
Solubility in water Completely soluble
Solubility (soluble in) Chloroform,Alcohol
Solubility (very slightly) Ether
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws:
EC Number 204-054-8
RTECS# BR3150000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
HS Number 2924297099
Application
競合的な抗コリンエステラーゼ阻害剤,ネオスチグミンブロミド

Neostigmine bromide, a synthetic physostigmine analog, is a competitive cholinesterase inhibitor. Unlike the plant alkaloid physostigmine [P0406], neostigmine bromide has a quaternary nitrogen, hence it more polar and does not cross the blood-brain barrier. Neostigmine bromide induces an increase in acetylcholine (ACh) in the synaptic cleft through reversible inhibition of its hydrolysis by acetylcholinesterase (AChE), and activates peripheral cholinergic nervous system. Neostigmine bromide used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as tubocurarine [C0433]. (The product is for research purpose only.)

References


PubMed Literature


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