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CAS RN: 155213-67-5 | Product Number: R0116

Ritonavir


Purity: >98.0%(HPLC)(N)
Synonyms:
Documents:
200MG
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1G
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Product Number R0116
Purity / Analysis Method >98.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__3__7H__4__8N__6O__5S__2 = 720.95  
Physical State (20 deg.C) Solid
CAS RN 155213-67-5
Reaxys Registry Number 7680098
PubChem Substance ID 253660208
Merck Index (14) 8238
MDL Number

MFCD00927142

Specifications
Appearance White to Almost white powder to crystaline
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 122.0 to 127.0 °C
Specific rotation [a]20/D +7.0 to +10.0 deg(C=2,MeOH)
Properties (reference)
Melting Point 125 °C
Specific Rotation 8° (C=2,MeOH)
Solubility in water Insoluble
Solubility (very soluble in) Ethanol
Solubility (slightly sol. in) Methanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P273 : Avoid release to the environment.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
Related Laws:
RTECS# XA5310000
Transport Information:
HS Number 2934100090
Application
Ritonavir: a Booster of Other Protease Inhibitors

Ritonavir was originally developed as an inhibitor of HIV protease inhibitor (PI). Ritonavir is currently exclusively used as a pharmacokinetic enhancer (booster) of other protease inhibitors, due to ritonavir's potent inhibition of the cytochrome P 450 3A4 (CYP3A4), an enzyme that is responsible for metabolizing most HIV PIs.

References


PubMed Literature


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