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CAS RN: 13553-79-2 | Product Number: R0200

Rifamycin S


Purity: >98.0%(HPLC)
Synonyms:
  • 1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin
Documents:
1G
€133.00
1   ≥20 
5G
€400.00
3   4  

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number R0200
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__3__7H__4__5NO__1__2 = 695.76  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 13553-79-2
Reaxys Registry Number 604802
PubChem Substance ID 354335535
Merck Index (14) 8217
MDL Number

MFCD06198807

Specifications
Appearance Light yellow to Brown powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 96.0 %
Specific rotation [a]20/D +451 to +500 deg(C=0.1, methanol)
Properties (reference)
Melting Point 201 °C
Specific Rotation 476° (C=0.1,MeOH)
Maximum Absorption Wavelength 390(MeOH) nm
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H371 : May cause damage to organs.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P405 : Store locked up.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 236-938-4
RTECS# KD1925000
Transport Information:
HS Number 2941900000
Application
Rifamycin S: A "Classic" Rifamycin with Potent Antimicrobial Activity but Poor Tolerability

Rifamycin S belongs to the family of ansamycin antibiotics, rifamycins. Initially, rifamycins were discovered referred to as rifamycin A, B, C, D, E in 1957. Among these, rifamycin B isolated in a pure form. Although its antimicrobial activity was moderate, it was oxidized and hydrolyzed to yield the highly active rifamycin S, a quinone molecular with potent antimicrobial activity but poor tolerability. Rifamycins inhibit DNA-dependent RNA polymerase in susceptible strains of bacteria, including Mycobacterium tuberculosis and Gram-positive bacteria. The rifamycin group includes the "classic" rifamycins as well as active rifamycin derivatives, rifampicin [R0079], rifaximin [R0101] and rifabutin [R0211]. (The product is for research purpose only.)

References


PubMed Literature


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